Evaluation of Curcumin and Dimethyl Chalcone in Neuropathic Pain Management Insights from In-Vivo Chronic Constriction Injury Model and Histological Analysis. In “The Journal of Carcinogenesis

The study titled “Evaluation of Curcumin and Dimethyl Chalcone in Neuropathic Pain Management: Insights from In-Vivo Chronic Constriction Injury Model and Histological Analysis”, published in The Journal of Carcinogenesis, investigates the neuroprotective and analgesic potential of two phytochemicals—curcumin and dimethyl chalcone—in mitigating neuropathic pain. Using the chronic constriction injury (CCI) model in experimental animals, the research explores behavioral, biochemical, and histological parameters to assess the efficacy of these compounds. The findings reveal that both curcumin and dimethyl chalcone significantly attenuate pain hypersensitivity, reduce oxidative stress, and improve nerve morphology compared to untreated groups. Histopathological evaluations further demonstrate preservation of axonal integrity and reduction in inflammatory cell infiltration, supporting their therapeutic relevance. This study provides valuable mechanistic insights into the modulation of neuroinflammation and oxidative pathways, highlighting curcumin and dimethyl chalcone as promising candidates for the development of safer and more effective treatments for neuropathic pain.

Congratulations to Dr. Sailendra Kumar Mahanta and all the co-authors for the publication titled.

Dr. Sailendra Kumar Mahanta

Professor and Associate Dean,

School of Pharmacy, The Assam Kaziranga University